Reliance Life Sciences offers a broad suite of services of interest to pharmaceutical and biotechnology organizations. Specifically, it has capabilities to address needs of its clients in chemistry, biology, formulation development, informatics, process development, and biopharmaceutical manufacturing.
Contract Biology Research Services
Reliance Life Sciences offers a variety of custom R&D solutions in biology. The services include:
- Gene Isolation, Cloning and Sequencing
- Protein Expression in bacteria, yeast, and mammalian cells
- Construction of cDNA and genomic DNA libraries
- Development and Purification of polyclonal and monoclonal antibodies
- Process Development for fermentation and purification of recombinant proteins
- Development of in vitro and cell-based assays
- Analytical Testing of protein products
Pre-clinical Research Services (An OECD GLP certified toxicology facility)
Reliance Life Sciences provides in-vivo efficacy and pre-clinical safety studies for cell-based therapies, proteins and new chemical entities.
The Laboratory Animal Research Services (LARS) Facility of Reliance Life Sciences is registered with the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) and conforms to its guidelines on developing reliable and reproducible scientific data while maintaining a healthy balance between animal ethics, welfare and experimentation.
Reliance Life Sciences provides the following services:
Specialized Animal Experimentation
- Studies in SPF rodents and Immuno-deficient mice
- Generation of polyclonal and monoclonal antibodies
- Development of animal models for human diseases
- Supply of specific surgical models of rats and mice
Toxicity and Efficacy
- Single dose toxicity Studies
- Repeated dose toxicity Studies
- Genotoxicity Studies
- Sensitization Studies
- Safety handler Studies
Related Services
- Histopathology
- Exploratory Toxicity Studies
- Clinical Biochemistry and Hematology
Other Services
- Genetic and Health Monitoring (specific micro organisms only) of laboratory rodents
- Consultancy for Animal House planning, design and layout
- Advanced Training Courses in laboratory animal management
- Contract Clinical Research Services
- Please see the Clinical Research Services section.
- Contract Manufacturing of Biopharmaceuticals
Reliance Life Sciences offers a complete spectrum of services for the manufacture of Biopharmaceuticals, ranging from Bioassay Development, Process Development, Analytical Testing to clinical lot and Commercial Batch Manufacture as per USFDA and EMEA requirements.
- Bioassay Development
- Development and validation of bioassays for various proteins using in vitro and in vivo techniques
- Virus-based Assays
- Radioisotope- based Assays
- Analytical Testing of proteins
- Isoelectric Focusing
- RP, IE and SE HPLC
- Peptide Mapping using HPLC
- MALDI -TOF
- Capillary Electrophoresis
- Mass Analysis of proteins
- Carbohydrate Analysis of glycoproteins using CE and Mass Spectrophotometry
- N-terminal Sequencing
- Upstream Bioprocess Development
- Cell line Development
- Microbial Fermentation (recombinant E. coli & P. pastoris) development
- Mammalian Cell Culture Development
- Media Optimization for Cell Cultivation
- Product Recovery (centrifugation/microfiltration) and Homogenization
- Inclusion Body Solubilization & Protein Refolding Optimization
- Downstream bioprocess development
- Analytical Method Development and Qualification Development
- Chromatographic Purification
- Tangential Flow Filtration
- Viral Filtration and Inactivation Development
- Formulation and Stability Studies
- Clinical Lot and Commercial Manufacture
Reliance Life Sciences can produce, on a contract basis, clinical lots and commercial batches of:
- Mammalian Cell Culture Proteins
- Batch, fed-batch, and perfusion operation
- Microbial Fermentation Proteins
- Batch and fed-batch processes
- Blood Plasma Products
- Fill Finish
- Vial Filling
- Pre-filled Syringes
- Lyophilzed Vials
